مقاله Two Lung Cancer Development-Related Genes, Forkhead Box M1 (FOXM1) and Apolipoprotein E (APOE), are overexpressed in Bronchial of Patients after Long-Term Exposure to Sulfur Mustard

مقاله Two Lung Cancer Development-Related Genes, Forkhead Box M1 (FOXM1) and Apolipoprotein E (APOE), are overexpressed in Bronchial of Patients after Long-Term Exposure to Sulfur Mustard

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مقاله Two Lung Cancer Development-Related Genes, Forkhead Box M1 (FOXM1) and Apolipoprotein E (APOE), are overexpressed in Bronchial of Patients after Long-Term Exposure to Sulfur Mustard دارای 10 صفحه می باشد و دارای تنظیمات در microsoft word می باشد و آماده پرینت یا چاپ است

فایل ورد مقاله Two Lung Cancer Development-Related Genes, Forkhead Box M1 (FOXM1) and Apolipoprotein E (APOE), are overexpressed in Bronchial of Patients after Long-Term Exposure to Sulfur Mustard کاملا فرمت بندی و تنظیم شده در استاندارد دانشگاه و مراکز دولتی می باشد.

توجه : در صورت  مشاهده  بهم ريختگي احتمالي در متون زير ،دليل ان کپي کردن اين مطالب از داخل فایل ورد مي باشد و در فايل اصلي مقاله Two Lung Cancer Development-Related Genes, Forkhead Box M1 (FOXM1) and Apolipoprotein E (APOE), are overexpressed in Bronchial of Patients after Long-Term Exposure to Sulfur Mustard،به هيچ وجه بهم ريختگي وجود ندارد


بخشی از متن مقاله Two Lung Cancer Development-Related Genes, Forkhead Box M1 (FOXM1) and Apolipoprotein E (APOE), are overexpressed in Bronchial of Patients after Long-Term Exposure to Sulfur Mustard :

سال انتشار : 2017

تعداد صفحات : 10

Sulfur mustard (SM) is a strong alkylating and mutagenic compound that targets humanairway system. We considered the expression of Forkhead box M1 (FOXM1) and apolipoproteinE (APOE) genes, which are responsible for cell proliferation, differentiation, tumorigenesis,and increased risk of lung cancer, in the lung bronchial tissue of patients exposed to SM.After performing pulmonary functional tests (PFTs), 11 human subjects (five controls and sixSM-exposed patients) were entered in this study. Total RNA were extracted from all biopsysamples and then cDNA was synthesised for each specimen using RT-PCR. Changes in geneexpression were measured using a RT2 Profiler ™PCR Array. PFTs have demonstrated moreobstructive and restrictive spirometric patterns among patients compared to the controls. Ahigher expression was recorded for both examined genes in bronchial of SM-exposed patients.Expression of FOXM1 and APOE genes in bronchial of the patients was significantly (p <0.001) overexpressed by 14.8316 and 3.9504-folds, respectively. Mustard lungs were associatedwith increased expression of FOXM1 and APOE genes, which suggests an increased risk oflung cancer among these patients. Since FOXM1 and APOE are considered as oxidative stressresponsive genes, we speculate that increased expression of these genes is more likely linked tooverproduction of reactive oxygen species (ROS) and oxidative stress (OS) in mustard lungs.Further studies are required at protein level among SM-exposed patients with lung cancer touse these genes as lung cancer biomarkers among these patients.

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